Jornal de Pesquisa em Dermatologia Clínica e Experimental
Acceso abierto

abstracto

LNGFR (CD271) como marcador para identificar células madre mesenquimales de diferentes fuentes humanas: sangre de cordón umbilical, gelatina de Wharton y médula ósea

Erika Ito, Motoki Nakamura, Shoichi Watanabe y Akimichi Morita

Background: Angiosarcoma is a malignant neoplastic disease that often occurs in older people. The prognosis is poor and treatment effectiveness remains controversial.

Objective: We examined cases of scalp angiosarcoma treated in Nagoya City University Hospital from 1985 to 2013 and retrospectively analyzed treatment effectiveness.

Methods and materials: We identified 21 scalp angiosarcoma patients and followed up 18 patients among them. Disease-specific survival was calculated by the Kaplan and Meier method and compared between treatments.

Results: Median patient age was 75 years, and 14 patients (78%) were over 70 years of age. The 2- and 5-year disease-specific survival was 62.7% and 26.3%, respectively. Overall survival was significantly longer in those receiving radiotherapy or combination therapy with radiotherapy and chemotherapy. Thirteen patients (72%) received chemotherapy and 12 patients received taxane-based chemotherapy. Although toxicity occurred in 11 patients receiving taxane-based chemotherapy, most cases were grade 1 or 2.

Conclusions: Combination therapy with radiotherapy and taxane-based chemotherapy may be an effective medical treatment for scalp angiosarcoma, and can be performed safely even in older patients