Revista de Hematología y Enfermedades Tromboembólicas
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abstracto

Effect of Poly-herbal Extract in Treatment of Experimentally Induced Hemolytic Anemia in Rabbits

Muhammad Ali Haide1*, Misbah Ijaz1, Haider Ali2

Anemia is a condition in which the body's oxygen transport capacity is reduced due to a drop in Hemoglobin (Hb) levels in the blood. Considering the beneficial effects of moringa, garlic, and coriander, the present study was proposed to determine the beneficial effect of feeding polyherbal extract in treating induced hemolytic anemia in the rabbit model. These herbs contain Iron, Vitamin C, Folate and B12 for the production of hemoglobin in the body. Anemia was induced by giving Phenyl hydrazine injections intra-peritoneally (20 mg/kg B.wt). After induction of hemolytic anemia in 24 rabbits, three equal groups were made. Group A was given iron sucrose (Inj. Monofer® 5 ml/kg B.wt) as it helps to recover the anemia immediately. Group B rabbits were given orally polyherbal extract (5 ml/kg B.wt). Group C was left untreated. The efficacy of the treatments was measured by analyzing the concentrations of biochemical parameters, hematological parameters, and iron on the 1^st, 7^th, 15^th, and 21^st days of treatment. A two-way analysis of variance was used to analyze the collected data. Results revealed that the mean ± SE values of hematological parameters like Hb, RBCs, MCH, MCV, and Fe were significantly decreased (P<0.01) at Day 0 while the values of all these parameters were significantly increased (P<0.01) at Day 21, after treatment with polyherbal extract. Based on the results of this study, it was concluded that polyherbal extracts of Moringa, coriander, and garlic have excellent anti-anemic properties and significantly improved the hematological and biochemical parameters.