Revista de Probióticos y Salud
Acceso abierto

abstracto

Impact of prebiotics on bone mineral metabolism in murine models: A systematic mini-review

Luisa Diaz-Garcia, Hector Avila-Rosas, Francisco Jimenez-Trejo

Calcium deficiency can occur throughout life. In children, calcium deficiency can manifest in its most serious
forms, such as rickets and fractures and as osteoporosis in adulthood. The findings from animal models suggest
that prebiotic supplementation has an impact on bone mineral density. The objective of this study was to evaluate
the effect of prebiotics on bone mineral metabolism in murine models as reported in the scientific literature. A
systematic review of the literature was carried out following international quality lines. The full texts were analyzed
using the guidelines of the ARRIVE guide; the Risk-of-Bias (RoB) tool for intervention studies according to the
SYRCLE. Twelve studies that met the inclusion criteria were included in the meta-analyses. The BMD of the spine
showed a positive response to supplementation with prebiotics Standardized Mean Difference (SMD= 0.38, 95%
Confidence Interval (CI), -0.29 to 1.04, p ≤ 0.0001). The BMD in the tibia showed the same trend (SMD= 0.87, 95%
CI -0.08 to 1.82, p≤0.0001). The calcium content in the femur (SMD= 15.78 95% CI, 5.69 to 25.87, p ≤ 0.0001) was
greater in supplemented animals than in the no supplemented animals, as was the magnesium content (SMD= 136,
95% CI, 0.34 to 2.38, p ≤ 0.0001). In Conclusion, Supplementation with prebiotics has positive effects on bone
mineral metabolism, specific to the amount or type of prebiotic, improves bone density and controls reabsorption.